Compare interventions

Use the same six evidence dimensions for both. This prevents a strong animal result for one product being compared with a human clinical result for another.

First intervention

versus

Second intervention

Performance and muscle

Creatine monohydrate

Useful human evidence

Useful evidence for strength and training support; longevity benefits would be indirect.

Human clinical outcomes Moderate

Human biomarkers Moderate

Animal lifespan Preliminary

Mechanistic plausibility Strong

Safety certainty Strong

Direct longevity relevance Limited

Verdict: Creatine monohydrate has a much stronger human evidence base than most products sold under a longevity label. Its clearest benefits concern high-intensity performance and gains from resistance training. In older adults, preserving strength and lean mass is plausibly relevant to healthspan, although creatine has not been shown to extend human life.

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NAD+ precursor

NMN

Early human evidence

Raises NAD-related biomarkers; broad healthspan benefits have not followed reliably.

Human clinical outcomes Preliminary

Human biomarkers Moderate

Animal lifespan Limited

Mechanistic plausibility Moderate

Safety certainty Limited

Direct longevity relevance Preliminary

Verdict: Nicotinamide mononucleotide can raise NAD-related measures in humans, which confirms biological activity. Trials have reported selected metabolic or functional effects, but results are mixed, studies are generally short, and no human evidence shows slower ageing or longer life.

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